Acute Pancreatitis treated with Insulin.

Chronic-PancreatitisPancreatitis is a condition that involves the causing severe , vomiting and systemic inflammation. Major causes include bile acid reflux from gall stones and excessive combined with a high fat diet with increased incidences during the Christmas period when alcohol and fat consumption is at its highest in the general population.

Pancreatitis occurs When alcohol and fat accumulate inside pancreatic acinar cells, depleting cellular energy levels and increasing cellular calcium. This causes uncontrolled and catastrophic and the cells burst, releasing their toxic enzymes which digest the and surrounding tissue.

A new study published in the Journal of Biological Chemistry shows that Insulin prevents the toxic impact of alcohol and fatty acid on the acting as a .

Diabetes worsens pancreatitis and diabetics are at higher of developing pancreatitis and multiple organ . Previous research has shown that in diabetics that receive insulin the incidence of pancreatisis is significantly reduced although the exact preventative mechanism was not understood.

“Insulin works by restoring the energy levels of pancreatic acinar cells, which fuels the calcium pumps on the membrane of these cells. These calcium pumps help to restore cellular calcium and prevent the catastrophic and auto-digestion of the ,” said Dr Bruce the senior .

Source

A. Samad, A. James, J. Wong, P. Mankad, J. Whitehouse, W. Patel, M. Alves-Simoes, A. K. Siriwardena, J. I. E. Bruce. Insulin protects pancreatic acinar cells from palmitoleic acid-induced cellular injury. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M114.589440

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