Autism rates liked to harmful environmental factors.

autismScientists from the University of Chicago analyzed over 100 million US and found a strong between autism rates and level of and possible indicators of harmful exposure to such as pesticides.

The study was published in the PLOS journal and revealed that autism rates exponentially exploded by 283 percent for every one percent increase in genital malformations in newborn males across the country. A similar rate was seen with a 94% increase in rates correlated with genital malformations. The linked genital malformations as an indicator of toxic . Numerous studies have documented the link between environmental toxins and new born abnormalities in a wide array of species. Male fetuses are particularly sensitive to toxins such as environmental lead, sex hormone analogs, medications and other synthetic . Parental exposure to these toxins is thought explain a large portion of congenital reproductive malformations, such as micropenis, hypospadias (urethra on underside of the penis), undescended testicles and others.

“Autism appears to be strongly correlated with rate of congenital malformations of the genitals in males across the country,” said Andrey Rzhetsky, PhD, professor of and human genetics at the University of Chicago. “This gives an indicator of environmental load and the effect is surprisingly strong.”

“We interpret the results of this study as a strong environmental signal,” Rzhetsky said. “For future genetic studies we may have to take into account where data were collected, because it’s possible that you can get two identical kids in two different counties and one would have autism and the other would not.”

Source

Andrey Rzhetsky, Steven C. Bagley, Kanix Wang, Christopher S. Lyttle, Edwin H. Cook, Russ B. Altman, Robert D. Gibbons. Environmental and State-Level Regulatory Factors Affect the Incidence of Autism and . PLoS Computational Biology, 2014; 10 (3): e1003518 DOI: 10.1371/journal.pcbi.1003518

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