Cardiovascular disease, stroke or diabetes may face 23 year reduction in life expectancy. New study finds that combination of conditions increases mortality rate.

bloodpressureA new study published by the University of Cambridge in the UK has determined that a number of conditions contributing to metabolic disease affecting the heart is increasing drastically with a shortened life expectancy. The current estimates specify that approximately 10 million adults within the European Union and the United States are affected.

The research study is the first to documents that a combination and history of two or more metabolic and cardiovascular conditions (stroke, heart attack or diabetes) may increase mortality risk.The analyzed data included 689,300 participants from the Emerging Risk Factors Collaboration conducted between 1960 and 20007. The control group consisted of data obtained from the UK biobank with 499,888 participants.
Data from the Emerging Rick Factors Collaboration included 128,843 deaths, while data from the UK Biobank included 7,995 deaths.

The research findings reveal that adults with two or more metabolic and heart conditions have a 23 year reduced life expectancy compared to individuals with no history of diabetes, heart attack or stroke. People who had a history of one of these conditions was found to have twice the rate of death. Each additional condition increased the death rate. The rate of death among participants with a history of two of these conditions was four times higher, while the rate of death increased eight-fold for participants who had all three conditions.

The research team estimated that a history of health conditions is associated with a reduced life expectancy similar to that caused by smoking and HIV. Younger individuals have a higher reduction in life expectancy and it is estimate that individuals aged 40 with a history of diabetes, stroke and heart attack could experience around 23 years of lost life.


Association of cardiometabolic multimorbidity with mortality, John Danesh et al., JAMA, doi: 10.1001/jama.2015.7008, published online 7 July 2015, abstract.

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