Coffee interacts with Gene Variant protecting against Parkinson enhancing its impact.

parkinson1Parkinson’s disease is a complicated neurological disease, where both and exposure to are involved

Previous studies have documented the protective impact of on Parkinson’s disease. The GRIN2A gene, a genetic variant, protects against the development of Parkinson’s disease. A study from two countries examined the combination of and the GRIN2A gene and if there were any significant changes.

The findings of this study reveal that molecular explanation for its protective effects against Parkinson’s disease and that integrates with a dopamine receptor that regulates the flow of calcium into the cell. Dopamine is part of the human , and the interaction of with it, it has been speculated that individuals with certain genetic variations are not “rewarded” to the same extent by a , and therefore would not enjoy the same protective effect as others. The newly published study revealed that there was a strong inhibitory significance of both and the GRIN2A gene on developing Parkinson’s disease.

The study results also suggest that there may be a significant epigenetic impact through environmental influence on genes linked to Parkinson.

Source

Naomi Yamada-Fowler, Mats Fredrikson, Peter Söderkvist. Interaction with Glutamate GRIN2A: Parkinson’s Disease in Swedish Population. PLoS ONE, 2014; 9 (6): e99294 DOI: 10.1371/journal.pone.0099294

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