Coffee prevents damaging impact of obesity

coffeeA new study, published in Pharmaceutical Research, has determined that a chemical compound commonly found in coffee may help prevent some of the damaging effects of obesity. Obesity has become a public health epidemic in the US with 1/3 of adults overweight and 17$ of children obese.

Chlorogenic acid, found in coffee, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet. Mice were fed a high fat diet for 15 weeks while injecting them with a CGA solution twice per week. CGA acted by preventing weight gain and helped maintain normal blood sugar levels and healthy liver composition.

“Previous studies have shown that coffee consumption may lower the risk for chronic diseases like Type 2 diabetes and cardiovascular disease,” said Yongjie Ma, a postdoctoral research associate in UGA’s College of Pharmacy and lead author of the paper. “Our study expands on this research by looking at the benefits associated with this specific compound, which is found in great abundance in coffee, but also in other fruits and vegetables like apples, pears, tomatoes and blueberries.”

“CGA is a powerful antioxidant that reduces inflammation,” said Ma, who works in the laboratory of professor Dexi Liu in the department of pharmaceutical and biomedical sciences. “A lot of evidence suggests that obesity-related diseases are caused by chronic inflammation, so if we can control that, we can hopefully offset some of the negative effects of excessive weight gain.”


Yongjie Ma, Mingming Gao, Dexi Liu. Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. Pharmaceutical Research, 2014; DOI: 10.1007/s11095-014-1526-9

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