Drinking and Smoking deadly combination. The risk of esophageal cancer doubles in those who smoke and drink.

smokingdrinkingA study published in the American Journal of Gastroenterology is the first review study to investigate the combination of both drinking and smoking and pointed out that the of developing esophageal squamous cell carcinoma (ESCC) doubles in those who both smoke and drink compared to those who only smoke or drink.

ESCC is on the rise with estimates of over 18,000 new diagnosed cases in 2014 and 15,000 linked death, based on statistics from the .

“Our study suggests that not only do alcohol and tobacco play an important role in the development of esophageal cancer, the combination of their use markedly increases their potency as carcinogens. As a result, we as physicians should focus efforts directed at controlling the burden of esophageal cancer on those who consume both of these substances,” said lead author Anoop Prabhu, MD, Advanced Endoscopy Fellow at the Icahn School of Medicine at Mount Sinai, in New York, NY.

“Our systematic review confirmed the expected exposure-dependent relationship of both alcohol and tobacco with the of ESCC, as alcohol use and tobacco use were both independent factors for the development of ESCC,” said Dr. Prabhu.

Source

Anoop Prabhu, Kenneth O Obi, Joel H Rubenstein. The Synergistic and Tobacco on the of Esophageal Squamous Cell Carcinoma: A Meta-Analysis. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.71

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