An opinion article published by Cell Press in the July 10th edition of the Journal Trends in Endocrinology & Metabolism has reviewed evidence on the negative impact of artificial sweeteners.
The prevailing research has suggested that the consumption of sugar-sweetened drinks has been linked to obesity, type 2 diabetes, and metabolic syndrome — a group of risk factors that raises the risk for heart disease and stroke. As a result, many Americans have turned to artificial sweeteners, which are hundreds of times sweeter than sugar but contain few, if any, calories. However, studies in humans have shown that consumption of artificially sweetened beverages is also associated with obesity, type 2 diabetes, and metabolic syndrome as well as cardiovascular disease. As few as one of these drinks per day is enough to significantly increase the risk for health problems and Researchers at Washington University School of Medicine in St. Louis have found that a popular artificial sweetener can modify how the body handles sugar.
In a small study, the researchers analyzed the sweetener sucralose (Splenda®) in 17 severely obese people who do not have diabetes and don’t use artificial sweeteners regularly.
“Our results indicate that this artificial sweetener is not inert — it does have an effect,” said first author M. Yanina Pepino, PhD, research assistant professor of medicine. “And we need to do more studies to determine whether this observation means long-term use could be harmful.”
Other research has linked consumption of artificial sweeteners with altered activation patterns in the brain’s pleasure centers in response to sweet taste, suggesting that these products may not satisfy the desire for sweets. Similarly, studies in mice and rats have shown that consumption of noncaloric sweeteners dampens physiological responses to sweet taste, causing the animals to overindulge in calorie-rich, sweet-tasting food and pack on extra pounds.
“It is not uncommon for people to be given messages that artificially-sweetened products are healthy, will help them lose weight or will help prevent weight gain,” says author Susan E. Swithers of Purdue University. “The data to support those claims are not very strong, and although it seems like common sense that diet sodas would not be as problematic as regular sodas, common sense is not always right.”
The findings suggest that artificial sweeteners increase the risk for health problems to an extent similar to that of sugar and may also exacerbate the negative effects of sugar. “These studies suggest that telling people to drink diet sodas could backfire as a public health message,” Swithers says. “So the current public health message to limit the intake of sugars needs to be expanded to limit intake of all sweeteners, not just sugars.”