Researchers from the University of California Department of Surgery in Los Angeles have published a new article in the FASEB Journal indicating that supplementation with fish oil products and antioxidants may be beneficial for Alzheimer disease patients.
The research participants consisted of 12 patients with minor cognitive impairment, 2 patients with pre-mild cognitive impairment, and 7 patients with Alzheimer disease. The patients consumed fish omega-3 fatty and antioxidants for 4-17 months and the researchers measured the phagocytosis of amyloid-beta 1-42 by flow cytometry and microscopy, the transcription of inflammatory genes by RT-PCR, the production of resolvin D1 by enzyme immunoassay, and the cognitive status by MMSE. The research findings revealed clearance of the hallmark amyloid-beta protein which characterizes Alzheimer’s disease and reduces inflammation in neurological tissue.
“Prevention of mild cognitive impairment progression is one of the best hopes,” said Milan Fiala, M.D., Research Professor at the University of California’s Department of Surgery in Los Angeles. “In addition to physical and mental exercises recommended by experts, this study suggests that nutrition is equally important.”
“We’ve known for a long time that omega-3 fatty acids and some antioxidants can be beneficial to people with a wide range of health problems, as well as protective for healthy people,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. “Now, we know that the effects of these supplements may extend to Alzheimer’s disease as well. Although these supplements are considered to be generally safe and are very easy to obtain, full-scale clinical trials are necessary to verify the findings of this research and to identify who might benefit the most.”
M. Fiala, R. C. Halder, B. Sagong, O. Ross, J. Sayre, V. Porter, D. E. Bredesen. -3 Supplementation increases amyloid- phagocytosis and resolvin D1 in patients with minor cognitive impairment. The FASEB Journal, 2015; DOI: 10.1096/fj.14-264218