There has been growing concern regarding exposure to Monsanto’s Glyphosate, (also referred to as Glyphosphate in the relevant Material data safety sheets www.agrian.com/pdfs/Helosate_Plus_Advanced_MSDS.pdf ), based Roundup herbicide.
A new study published in the journal of Entropy specified that the microbial destruction of gut fauna and flaura may link autism rates to glyphosate exposure. Previous studies have documented that autistic children in particular have abnormal gut fauna and flaura and dietary intervention to restore the healthy gut microbial activity has an impact on symptoms and behavior of autistic children.
Numerous studies have documented the link of Autism Spectrum Disorder and impairment of the GI tract.
Autism spectrum disorders (ASD) are serious developmental disorders with soaring prevalence, affecting 1 in 91 children in the United States. ASD are characterized by a spectrum of symptoms, including decreased verbal skills and social withdrawal, repetitive behavior, insistence to routines, and unusual response to sensory stimuli.
A 2002 study initiated by the Department of Pediatrics at the university of Maryland documented the connection between ASD and GI disturbances and that ASD symptoms decreased significantly as GI symptoms were addressed.
A recent 2011 study in the Journal of Developmental Pediatrics examined the prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. It was found that increased ASD symptoms was characterized with a higher incidence of GI symptoms.
Parents reported significantly more GI problems in children with ASD (249/589; 42%) compared with their unaffected siblings (20/163; 12%) (p < .001). The 2 most common Gl problems in children with ASD were constipation (116/589; 20%) and chronic diarrhea (111/589; 19%). Conditional logistic regression analysis showed that having Full Autism (adjusted odds ratio [AOR] = 14.28, 95% confidence interval [CI]: 6.22-32.77) or Almost Autism (AOR = 5.16, 95% CI 2.02-13.21) was most highly associated with experiencing GI problems. Increased autism symptom severity was associated with higher odds of GI problems (AOR for trend = 2.63, 95% CI: 1.56-4.45).
Dr. Seneff presented research in her paper detailing the clear evidence that the potent herbicide disrupts a pathway that interferes with microbial gut activity and correlated the link of increased glyphospate exposure with increased autism rates.
Glyphosate’s claimed mechanism of action in plants is the disruption of the shikimate pathway, which is involved with the synthesis of the essential aromatic amino acids, phenylalanine, tyrosine, and tryptophan. This pathway is present in gut bacteria who have an integrated symbiotic relationship with their human host. In addition to aiding digestion, the gut microbiota synthesize vitamins, detoxify xenobiotics, and participate in immune system homeostasis and gastrointestinal tract permeability. Clear evidence was found that glyphosate disrupts gut bacteria and suppresses the CYP enzyme class, correlating a strong link between autism and the increased application of herbicides.
Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy 2013, 15, 1416-1463. Anthony Samsel 1 and Stephanie Seneff