Gut bacteria produces artherosclerosis in patients with chronic kidney disease

artherosclerosisA new study published by the Journal of the American Society of Nephrology has revealed that produce a byproduct involved and responsible for the formation of cholesterol plaques.

Artherosclerosis occurs in patients with chronic , leading to the development of heart disease and death. Intestinal bacteria produces an byproduct, (Trimethylamine-N-oxide (TMAO)), responsible for the initiation of cholesterol plaques in the arteries of individuals with decreased function.
Trimethylamine-N-oxide is generated as an byproduct as intestinal bacteria metabolize dietary nutrients called choline and L-carnitine.

Previous has specified that rodents who consumed TMAO and humans who had a higher concentration of TMAO in the blood suffered from an increased risk of developing heart disease and artherosclerosis. The kidneys maintain low blood levels of the compound by reducing toxic byproducts from the body.

The study findings revealed that blood levels of TMAO increased as function declined. A separate participants group, consisting of 220 patients, had high levels of TMAO in the linked with an increased risk of death over a 4 year period and an increased risk of atherosclerosis.

“Based on evidence that TMAO production is dependent on the metabolism of specific dietary constituents by intestinal bacteria, therapies targeting the generation of TMAO precursors by intestinal bacteria may represent a novel strategy for reducing and mortality in patients with CKD,” said Dr. Jason Stubbs from the Institute at the University of Kansas Medical Center.

Source

J. R. Stubbs, J. A. House, A. J. Ocque, S. Zhang, C. Johnson, C. Kimber, K. Schmidt, A. Gupta, J. B. Wetmore, T. D. Nolin, J. A. Spertus, A. S. Yu. Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden. Journal of the American Society of Nephrology, 2015; DOI: 10.1681/ASN.2014111063
W. H. W. Tang. Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD. Journal of the American Society of Nephrology, 2015; DOI: 10.1681/ASN.2015050576

Be Sociable, Share!

    Leave a Reply

    Your email address will not be published. Required fields are marked *