Gut bacteria protects against diet induced inflammation and weight gain.

gutbaceriaA new study published in the journal Cell has determined that protects against diet induced weight gain and when mice were exposed to a fish diet compared against a lard diet.

Mice were fed with fish or lard for 11 weeks and monitored of metabolic and had very different . The fish diet increased the abundance of bacteria called Akkermansia muciniphila, known to reduce weight gain and improve glucose in mice.

“We wanted to determine whether gut microbes directly contribute to the metabolic differences associated with diets rich in healthy and unhealthy fats,” said first Robert Caesar of the University of Gothenburg. “Even though the study was done in mice, our goal is to identify interventions for optimizing metabolic in humans.”

“We were surprised that the lard and the fish diet, despite having the same energy content and the same amount of dietary fiber–which is the primary energy source for the –resulted in fundamentally different gut microbiota communities and that the microbiota per se had such large effects on ,” Caesar said.

The researchers indicate that the bacteria Akkermansia muciniphila is a promoter of a healthy phenotype, but further is needed to determine if bacteria can be used as a probiotic strain.


Caesar et al. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT through TLR Signaling. Cell , 2015 DOI: 10.1016/j.cmet.2015.07.026

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