High amount of Sugar causes liver damage.

A new study, published in the American , conducted with an animal at shows that dietary fructose causes even without the weight gain. The researchers found that doubled in animals over a six week period who were fed a high compared to the control group.

“Is a calorie a calorie? Are they all created equal? Based on this study, we would say not,” said Kylie Kavanagh, D.V.M., assistant professor of pathology- at Wake Forest Baptist and lead author of the study.

In a previous trial which is referenced in the article, Kavanagh’s team studied monkeys who were allowed to eat as much as they wanted of low-fat food with added fructose for seven years, as compared to a control group fed a low-fructose, low-fat diet for the . Not surprisingly, the animals allowed to eat as much as they wanted of the high- gained 50 percent more weight than the control group. They developed diabetes at three times the rate of the control group and also developed hepatic steatosis, or non- disease.

The big question for the researchers was what caused the . Was it because the animals got fat from eating too much, or was it something else?

To answer that question, this study was designed to prevent weight gain. Ten middle-aged, normal weight monkeys who had never eaten fructose were divided into two groups based on comparable and . Over six weeks, one group was fed a calorie-controlled diet consisting of 24 percent fructose, while the control group was fed a calorie-controlled diet with only a negligible amount of fructose, approximately 0.5 percent.

Both diets had the same amount of fat, carbohydrate and protein, but the sources were different, Kavanagh said. The high-fructose group’s diet was made from flour, butter, pork fat, eggs and fructose (the main ingredient in corn syrup), similar to what many people eat, while the control group’s diet was made from healthy complex carbohydrates and soy protein.

Every week the research team weighed both groups and measured their , then adjusted the amount of food provided to prevent weight gain. At the end of the study, the researchers measured biomarkers of through blood samples and examined what type of bacteria was in the intestine through fecal samples and intestinal biopsies.

“What surprised us the most was how quickly the liver was affected and how extensive the damage was, especially without weight gain as a factor,” Kavanagh said. “Six weeks in monkeys is roughly equivalent to three months in humans.”

In the high-fructose group, the researchers found that the type of intestinal bacteria hadn’t changed, but that they were migrating to the liver more rapidly and causing damage there. It appears that something about the high fructose levels was causing the intestines to be less protective than normal, and consequently allowing the bacteria to leak out at a 30 percent higher rate, Kavanagh said.

One of the limitations of the study was that it only tested for fructose and not dextrose. Fructose and dextrose are simple sugars found naturally in plants.

“We studied fructose because it is the most commonly added sugar in the American diet, but based on our study findings, we can’t say conclusively that fructose caused the ,” Kavanagh said. “What we can say is that high added sugars caused bacteria to exit the intestines, go into the blood stream and damage the liver.

“The began even in the absence of weight gain. This could have clinical implications because most doctors and scientists have thought that it was the fat in and around tissues in the body that caused the health problems.”

Journal Reference:

Kylie Kavanagh, Ashley T Wylie, Kelly L Tucker, Timothy J Hamp, Raad Z Gharaibeh, Anthony A Fodor, and John M Cullen. Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. Am J Clin Nutr, June 19, 2013 DOI: 10.3945/ajcn.112.057331

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