High dose supplementation with Vitamin E and Selenium increases the risk of prostate cancer.

seleniumviteA large scale research study, involving more than 35,000 men, led by the Fred Hutchinson Cancer Research Center has determined a higher risk of prostate cancer with the consumption of selenium and vitamin E.

The research was published in the Journal of the National Cancer Institute and the basis of the research was to investigate whether taking high-dose vitamin E (400 IU/day) and/or selenium (200 mcg/day) supplements could protect men from prostate cancer.

The cancer trial began in 2001 and was stopped in 2008 as vitamin E consumption pointed to an increased risk of prostate cancer. Two years after the trials were halted men who ingested vitamin E supplements had a 17 % increased risk of obtaining cancer. Selenium supplementation increased cancer in men who had a high selenium level to begin with, by 91%. After supplementation the levels of selenium became toxic where men had a high selenium level to begin with.

The study determined a correlating effect with selenium and vitamin E where low baseline levels of selenium and additional supplementation with vitamin E increased the risk of prostate cancer by 63% and the risk of aggressive prostate cancer by 11%.

“Many people think that dietary supplements are helpful or at the least innocuous. This is not true,” said corresponding and first author Alan Kristal, Dr.P.H., a faculty member in the Public Health Sciences Division of Fred Hutch. “We know from several other studies that some high-dose dietary supplements — that is, supplements that provide far more than the daily recommended intakes of micronutrients — increase cancer risk. We knew this based on randomized, controlled, double-blinded studies for folate and beta carotene, and now we know it for vitamin E and selenium.”

“These supplements are popular — especially vitamin E — although so far no large, well-designed and well-conducted study has shown any benefits for preventing major chronic disease,” Kristal said.

“Men using these supplements should stop, period. Neither selenium nor vitamin E supplementation confers any known benefits — only risks,” he continued. “While there appear to be no risks from taking a standard multivitamin, the effects of high-dose single supplements are unpredictable, complex and often harmful. Taking a broad view of the recent scientific studies there is an emerging consistency about how we think about optimal intake of micronutrients. There are optimal levels, and these are often the levels obtained from a healthful diet, but either below or above the levels there are risks.”


Alan R. Kristal, Amy K. Darke, J. Steven Morris, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, Frank L. Meyskens, Jr, Gary E. Goodman, Lori M. Minasian, Howard L. Parnes, Scott M. Lippman, and Eric A. Klein. Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk. Journal of the National Cancer Institute, February 2014 DOI: 10.1093/jnci/djt456

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