High fat diet affects Sleeping patterns.

A new research study from the University of California Irvine, has demonstrated that a high fat diet affects a persons sleeping patterns. The disruption has been traced back to the metabolic functions in the liver that are affected by the high fat diet causing diabetes, obesity and high blood pressure.

Returning to a balanced low fat diet normalizes the rhythms revealing that that the internal body clock also called a circadian clock is able to reprogram itself in response to a change of nutrition.

The influence of a high-fat diet is controlled by regulator genes. One blocks normal cycles by impeding the clock regulator genes called CLOCK:BMAL1. The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma. These genes are primarily involved in an inflammatory response which results in a wide array of health conditions.

The circadian body clock is instrumental in controlling the circadian rhythms of 24 hours that determine the basic physiological functions in virtually all organisms. The clock acts as an environmental cue adapting itself to environmental changes and any changes to these rhythms can substantially affect health and cause a wide range of negative health conditions.


Kristin L. Eckel-Mahan, Vishal R. Patel, Sara de Mateo, Ricardo Orozco-Solis, Nicholas J. Ceglia, Saurabh Sahar, Sherry A. Dilag-Penilla, Kenneth A. Dyar, Pierre Baldi, Paolo Sassone-Corsi. Reprogramming of the Circadian Clock by Nutritional Challenge. Cell, 2013; 155 (7): 1464 DOI: 10.1016/j.cell.2013.11.034

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