High levels of insulin lead to obesity.

press1A new study has identified a crucial link between high levels of and pathways that lead to obesity. Providing mice with high levels of to prevent diabetes fosters the biochemical pathways leading to obesity.

blocks the secretion of glucagon, acts antagonistically on the and instructs the body to take up glucose from the blood.

Type 2 diabetics cannot respond properly to and have uncontrolled glucagon production, thereby causing their livers to overproduce glucose, contributing to high blood-sugar levels. is often given to people with to try to overcome -resistance and lower the levels of glucose in the .

, however, signals the body to produce fat especially with the high levels needed to control excess glucose. Therefore, the mice who were provided with the glucose ended up fat.

“We found that mice lacking the receptor for glucagon cannot get fat unless they are given the high levels of found in mice (and humans) that have ,” said Dr. Michael Roth, Professor of Biochemistry at UT Southwestern Roth, who holds the Diane and Hal Brierley Distinguished Chair in Biomedical Research. “This result suggests that the high levels of found in those who develop resistance and are a contributor to obesity and its complications.”

The researchers suggest that treating patients who have with higher than normal amounts of could contribute to the development of obesity. Medical doctors may need to reconsider the use of intensive therapy to control hyperglycemia (high blood-sugar levels) in obese, diabetic patients with hyperinsulinemia (overproduction of ). Suppressing glucagon action could prevent hyperinsulinemia, without causing diabetes. The research team found that suppressing glucagon in obese, -resistant, type 2 diabetic mice reduced blood glucose back to normal levels. The findings suggest that high levels actually aggravate diabetes by causing obesity.


Young Lee, Eric D. Berglund, Xinxin Yu, May-Yun Wang, Matthew R. Evans, Philipp E. Scherer, William L. Holland, Maureen J. Charron, Michael G. Roth, and Roger H. Unger. Hyperglycemia in rodent models of requires -resistant alpha cells. Proceedings of the National Academy of Sciences, August 2014 DOI: 10.1073/pnas.1409638111

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