High vitamin D levels just as damaging as low vitamin D, increases mortality rate

vitamindResearchers from the University of Copenhagen have for the first time demonstrated a correlation between high levels and cardiovascular deaths. is not water soluble but consists of a group of fat-soluble sterols necessary for normal bone growth, especially 2 (ergocalciferol) and (cholecalciferol). is generally found in milk, fish, and eggs and can be produced in the skin on exposure to sunlight.

has been associated with a significant public health burden as a dietary lack of in the diet can cause rickets in children. Now this study suggests that there are significant associates with high levels of consumption.

The study examined the consumption in 247,574 Danes who were followed for a 7 year period and their subsequent

“We have studied the level of in 247,574 Danes, and so far, it constitutes the world’s largest basis for this type of study. We have also analysed their over a seven-year period after taking the initial blood sample, and in that time 16,645 patients had died. Furthermore, we have looked at the connection between their deaths and their levels of ,” said Peter Schwarz, Professor at the Department of Clinical Medicine.

Out of the 247,574 participants a total of 16.645 subjects died in the ensuing 0–7 years. 5,454 died from cardiovascular disease including 1,574 from stroke and 702 acute myocardial infarct. 25-hydroxyvitamin D level of 70 nmol/L was associated with the lowest cardiovascular disease mortality risk. Men had a higher than women. Results were similar for stroke and acute myocardial subgroups

“If your level is below 50 or over 100 nanomol per litre, there is an greater connection to deaths. We have looked at what caused the death of patients, and when numbers are above 100, it appears that there is an increased risk of dying from a stroke or a coronary. In other words, levels of should not be too low, but neither should they be too high. Levels should be somewhere in between 50 and 100 nanomol per litre, and our study indicates that 70 is the most preferable level,” said Schwartz.

The researchers recommend that should only be taken upon consultation with the relevant medical professional.


Darshana Durup, Henrik Løvendahl Jørgensen, Jane Christensen, Anne Tjønneland, Anja Olsen, Jytte Halkjær, Bent Lind, Anne-Marie Heegaard, Peter Schwarz. A reverse J-shaped association between serum 25-hydroxyvitamin D and cardiovascular disease mortality – the CopD-study. The Journal of Clinical Endocrinology & Metabolism, 2015; jc.2014-4551 DOI: 10.1210/jc.2014-4551

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