Scientists have identified the ingredient in honey that kills bacteria. Bees generate a protein called defensin-1, which can be used to treat burns and skin infections and to develop new drugs that could combat antibiotic-resistant infections.
“We have completely elucidated the molecular basis of the antibacterial activity of a single medical-grade honey, which contributes to the applicability of honey in medicine,” said Sebastian A.J. Zaat, Ph.D., a researcher involved in the work from the Department of Medical Microbiology at the Academic Medical Center in Amsterdam. “Honey or isolated honey-derived components might be of great value for prevention and treatment of infections caused by antibiotic-resistant bacteria.”
Zaat and his team investigated the antibacterial activity of medical grade honey in test tubes against a panel of antibiotic-resistant, disease causing bacteria. A method was developed to selectively neutralize the known antibacterial factors in honey and determine their individual antibacterial contributions. Using this approach, researchers isolated the defensin-1 protein, which is part of the honey bee immune system and is added by bees to honey. After analysis, the scientists concluded that the vast majority of honey’s antibacterial properties come from that protein.
“We’ve known for millennia that honey can be good for what ails us, but we haven’t known how it works,” said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, “Now that we’ve extracted a potent antibacterial ingredient from honey, we can make it still more effective and take the sting out of bacterial infections.”