Inflammation in patients with type 2 diabetes reduced, through low-carbohydrate diet.

diabetes1A new study, published in the Annals of Medicine by Linköping University in Sweden, has revealed that a low-fat diet reduces the level of inflammation in the body of type 2 diabetes patients.

Previous studies have revealed that patients with type 2 diabetes have a higher level of inflammation in their body contributing to a higher risk of cardiovascular disease and other health associated problems.

Sixty one patients with type 2 diabetes took part in a clinical trial at Linköping University, conducted over two years, consisting of consuming a low-carbohydrate diet compared with a traditional low-fat diet. Prior to taking part in the study diabetic patients had higher inflammatory markers at baseline. The patients were examined 6 months after the start of the study, revealing that the level of inflammation in the low carbohydrate diet was significantly reduced. The weight loss in both groups was the same.

The study results confirm the results of a larger study involving 2330 diabetic participants, conducted at the Mario Negri Institute of Pharmacological Research, Milan, Italy. A total of 22,295 participants were actively followed for 11 years.

To assess dietary habits, all participants completed a questionnaire, and the researchers constructed a 10-point Mediterranean diet score (MDS) and a similar scale to measure the available carbohydrate (or glycaemic load [GL]) of the diet.

The findings reflect that people with an Mediterranean diet score over 6 were 12% less likely to develop diabetes than those with the lowest MDS of 3 or under. Patients with the highest available carbohydrate in their diet were 21% more likely to develop diabetes than those with the lowest. A high MDS combined with low available carbohydrate reduced the chances of developing diabetes by 20% as compared with a diet low in MDS and high in GL.


Lena Jonasson, Hans Guldbrand, Anna K. Lundberg, Fredrik H. Nystrom. Advice to follow a low-carbohydrate diet has a favourable impact on low-grade inflammation in type 2 diabetes compared with advice to follow a low-fat diet. Annals of Medicine, 2014; 46 (3): 182 DOI: 10.3109/07853890.2014.894286

Diabetologia. “Both a Mediterranean diet and diets low in available carbohydrates protect against type 2 diabetes, study suggests.”

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