Inflammation, obesity and cancer are related.

riskA new international study, published in the Lancet Oncology, revealed that 5.4% of cases in women and 1.9% of cases in men are linked to a high BMI. The qualitative analysis of in men include the esophagus, bowel, kidneys, pancreas and in women the gallbladder, ovaries, uterus and postmenopausal breast .

Obesity is associated with surplus body fat, interfering with various hormone cycles and with glucose and fat . Abdominal fat is associated with and an increased level of inflammation throughout the body. A BMI () of between 18.5 and 24.9 is considered normal but, a BMI of more than 25, is considered to be overweight.

“People with a BMI of 30 and above are predominantly affected”, said Alexandra Kautzky-Willer, Vice Principal of the University Department of Internal Medicine III of MedUni Vienna and member of the Comprehensive Center (CCC) Vienna. “An increase in BMI by only a factor of 1, for example from 29 to 30, increases your risk by between 3% and 10% for the said types of . Particularly abdominal fat, also known as visceral fat, has a on , since it increases your risk and encourages the development of metabolic disorders such as diabetes, or cardiovascular disease.”

The risk is increased as fatty tissue is hormonally active, produces adipose tissue hormones and changes the balance of sex hormones. This encourages the development and growth of hormone-related tumous, such as various forms of breast or endometrial . is encouraged by the detrimental shift in the balance of sex hormones and adipose tissue hormones. It also leads to an increase in insulin resistance, which the body responds to in turn by increasing .

“The problem with that is that insulin not only regulates the but can also act as a growth-stimulating hormone and encourage cell division and hence , said Kautzky-Willer. “We can therefore see a close relationship between diabetes and certain types of , in particular liver and pancreatic ”. ” Another aspect is that chronic inflammatory processes can occur in the region of the abdominal fat and these also favor the development of ”. “The positive thing is that you can do something about this risk by losing weight or keeping an eye on your weight from the outset. Many types of could be easily avoided in this way; a and exercise also help.”

Source

Melina Arnold, Nirmala Pandeya, Graham Byrnes, Andrew G Renehan, Gretchen A Stevens, Majid Ezzati, Jacques Ferlay, J Jaime Miranda, Isabelle Romieu, Rajesh Dikshit, David Forman, Isabelle Soerjomataram. Global burden of attributable to high body-mass index in 2012: a population-based study. Lancet Oncology, May 2015 DOI: 10.1016/S1470-2045(14)71123-4

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