Insulin resistance linked to Gene

geneA new study has determined that a gene variant is responsible for resistance, highlighting how little researchers actually know about the disease. Diabetes has become a global burden and approximately one third of the U.S. population has resistance.

resistance occurs in the vast majority of patients who eventually develop and seems to be a necessary, but not sufficient, abnormality leading to hyperglycemia in these individuals. -resistant persons who continue to secrete are still at increased risk to develop . It is estimated that 25% to 33% of the US population is sufficiently resistant to be at risk for adverse clinical consequences.

The research analysis by Stanford University examined the in over 5,000 individuals and found that the presence of one specific gene variant, called -acetyltransferase 2 (NAT2) is associated with for diabetes and .

Using a mouse model the researchers found that inhibiting the NAT2 gene homolog decreased sensitivity. A homolog is defined as a member of a chromosome pair. The NAT@ gene has not been previously associated with resistance.


Identification and validation of N-acetyltransferase 2 as an sensitivity gene J Clin Invest. 2015;125(4):1739–1751. doi:10.1172/JCI74692.

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