Low vitamin D levels linked to increased risk of diabetes.

vitdAnther study has been added to the growing volume of literature that documents that low vitamin D levels are associated with a higher risk of type 1 diabetes in children.

The most current research originates from a collaboration with the Institute of Diabetes Research (IDF) and the Helmholtz Zentrum München, a member of the German Center for Diabetes Research (DZD), as well as from the Diabetes Research Group at the Technische Universität München (TUM), and links low vitamin D levels in blood prior to the onset of diabetes.

“Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response,” one author says. “In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending vitamin D supplementation at an early stage of type 1 diabetes.”

The vitamin D levels are linked to an immune response with children who have not yet developed clinical type 1 diabetes, where prediabetes is defined as the presence of multiple islet autoantibodies. Low vitamin D levels are associated with multiple positive autoantibodies in their blood. The research team headed by Jennifer Raab, Dr. Christiane Winkler and Professor Anette-Gabriele Ziegler compared the vitamin D measurements taken from 108 children who were tested positive for islet autoantibodies with 406 children without autoantibodies. Lower vitamin D levels were also found in 244 children who had recently been diagnosed with type 1 diabetes.

Professor Ziegler one of the lead study authors commented as follows: “Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response. In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending vitamin D supplementation at an early stage of type 1 diabetes.”

Source

Jennifer Raab, Eleni Z. Giannopoulou, Simone Schneider, Katharina Warncke, Miriam Krasmann, Christiane Winkler, Anette-Gabriele Ziegler. Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression. Diabetologia, 2014; DOI: 10.1007/s00125-014-3181-4

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