Malnourishment causes DNA changes.

dietA study published in the International Journal of Epidemiology, by researchers at ’s Mailman School of and Leiden University in the Netherlands, determined that malnourishment during affected children adversely.

This is the first study to look at prenatal and -wide DNA patterns in adults exposed to severe under- at different periods of gestation. The period of gestation was 10 weeks of . The long term effect was associated with a 10 percent increase in mortality at the age of 63 years.

Malnourishment was defined as 900 calories or less, during the Dutch Hunger Winter of 1944-1945, affecting -wide DNA methylation levels. The study group consisted of 422 individuals exposed to the famine at any time during gestation and 463 controls without prenatal famine exposure.

The exhibited associations between famine exposure during weeks 1-10 of gestation and DNA changes, but not later in . DNA methylation changes were also seen among individuals conceived at the height of the famine between March and May 1945 who were not exposed to all 10 weeks of early gestation.

“The first ten weeks of gestation is a uniquely sensitive period when the blood methylome, or whole- DNA methylation, is especially sensitive to the prenatal environment,” said L.H. Lumey, MD, PhD, associate professor of Epidemiology at the Mailman School of , and last author. “This is the period when a woman may not even be aware that she is pregnant.”

The researchers recommend using the to see if DNA-methylation can make a difference for obesity and in this population. Other studies have revealed that type 1 diabetes, is caused by epigenetics, caused by nutritional changes.


E. W. Tobi, R. C. Slieker, A. D. Stein, H. E. D. Suchiman, P. E. Slagboom, E. W. van Zwet, B. T. Heijmans, L. Lumey. Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome. International Journal of Epidemiology, 2015; DOI: 10.1093/ije/dyv043

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