Mediterranean diet linked to additional health benefits. Reduces level of inflammation in body.

medit1There is a large volume of research detailing the heart healthy benefits of the Mediterranean diet. Now another study, published in the journal Blood, has tied the diet to lower levels of platelets and white blood cells; symptoms of inflammation in the body.

High platelet counts are associated with both vascular disease and non-vascular conditions such as cancer, and a high white blood cell count is a predictor of ischemic vascular disease. Both are used as markers to measure the rate of inflammation in the body.

The Mediterranean diet consists of servings of vegetables, fruit, whole grains, fish and olive oil and this study consisted of a large scale analysis of 15,000 healthy Italian men and women aged 35 or older.

The research participants were evaluated before the study and were confirmed as generally healthy. Total platelet counts and white blood cell counts were measured and participants were grouped according to their levels (low, normal, or high), based on age- and gender-specific cut-offs. In general people with high platelet levels were younger and had a greater incidence of high cholesterol and increased levels of common inflammation marker C-reactive protein when compared to those in the normal or low platelet categories. Individuals in the high white blood cell category were mainly younger, male, and smokers, and had a higher body-mass index and higher levels of C-reactive protein and blood glucose than those in the other groups. They also showed higher prevalence of high blood pressure and high cholesterol.

The research findings quite clearly revealed that consumption of the Mediterranean diet was directly related to lower levels of platelets and white blood cells, which in turn correlated to lower levels of inflammation. When compared with participants who did not follow the eating plan as closely, those who strictly followed a traditional Mediterranean diet were less likely to belong to study cohorts with relatively high platelet counts and were more likely to belong to cohorts with relatively low white blood cell counts.

“We undertook this study to understand the correlation between consuming a Mediterranean diet and specific health markers, including platelet levels and white blood cell counts, which can more specifically explain the diet’s benefits in reducing the long-term risk of cerebral and heart disease or other chronic conditions,” said lead study author Marialaura Bonaccio, PhD, of the Department of Epidemiology and Prevention at the IRCCS Istituto Neurologico Mediterraneo NEUROMED in Italy.

“Because the study included healthy participants, the lower levels of platelets and white blood cells in those who were more strictly consuming a Mediterranean diet indicate that this eating plan could account for substantial changes within normal ranges of variability. This is an important finding that has implications for how these anti-inflammatory markers are tracked among the general population,” added Dr. Bonaccio.

“An important finding of this study is that it indicates that the Mediterranean diet as a whole, and not just a few specific ingredients, is likely responsible for the beneficial health outcomes among the healthy population and should be encouraged as part of healthy eating habits,” said Dr. Bonaccio. “Building on these important findings, we continue to study this population to determine if the dietary habits may have an influence on cardiovascular disease-related mortality.”


M. Bonaccio, A. Di Castelnuovo, A. De Curtis, S. Costanzo, M. Persichillo, M. B. Donati, C. Cerletti, L. Iacoviello, G. de Gaetano. Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study. Blood, 2014; DOI: 10.1182/blood-2013-12-541672

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