Mediterranean diet reduces blood pressure and causes epigenetic changes.

mediterranean-pasta-saladAnother study has arrived which confirms the positive impact of the on blood pressure.

The includes found in olive oil, nuts and avocados, along with like spinach, and carrots that are rich in nitrites and nitrates. When these two groups are combined, the reaction of unsaturated fatty acids with nitrogen compounds in the results in the formation of nitro fatty acids.

The research was conducted by the King’s College in London; published in the PNAS journal and examined the process by which these nitro fatty acids lowered blood pressure. and whether they inhibited an enzyme known as soluble Epoxide Hydrolase.

Mice models were used and consisted of genetically engineered mice and normal mice. The normal mice were found to have lowered blood pressure by combining and abundant in nitrite and nitrate, through the of Epoxide Hydrolase.

In another study, the epigenetic changes caused by the were examined and the association with a lowered risk of cardiovascular problems, stroke and heart failure. These foods change how associated with atherosclerosis function.

The study consisted of three groups of healthy volunteers, where the first group consumed a traditional with virgin olive oil rich in polyphenols; the second group consumed a traditional with an olive oil low in polyphenols and the third group followed their habitual diet.

An analysis after three months revealed that the first group had an impact on the down-regulation in the expression of atherosclerosis-related in their peripheral blood mononuclear . Olive oil polyphenols were also involved on the expression of genetic changes influencing . Overall health was impacted with an effect on lipid and DNA oxidation, resistance, ,  carcinogenesis, and tumor suppression.

“This study is ground breaking because it shows that olive oil and a affect our bodies in a far more significant way than previously believed,” said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. “Not only does this research offer more support for encouraging people to change their eating habits, it is an important first step toward identifying drug targets that affect how our express themselves.”

Source
V. Konstantinidou, M.-I. Covas, D. Munoz-Aguayo, O. Khymenets, R. de la Torre, G. Saez, M. del Carmen Tormos, E. Toledo, A. Marti, V. Ruiz-Gutierrez, M. V. Ruiz Mendez, M. Fito. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the : a randomized controlled trialThe FASEB Journal, 2010; DOI: 10.1096/fj.09-148452

Rebecca L. Charles, Olena Rudyk, Oleksandra Prysyazhna, Alisa Kamynina, Jun Yang, Christophe Morisseau, Bruce D. Hammock, Bruce A. Freeman, and Philip Eaton. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolasePNAS, May 2014 DOI: 

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