Memory loss caused by insulin resistance, risk factor for Alzheimer’s disease

Insulin-Resistance-1A new study, published by Iowa State University in the Journal of the American Medical Association Neurology, has specified that caused by resistance increases the risk of Alzheimer’s disease.   resistance occurs predominantly in people suffering from obesity, pre-diabates and .

The researchers examined brain scans of 150 late middle-aged participants;  at risk for Alzheimer’s disease, but showed no sign of . Participants with higher levels of resistance do not have proper and used less blood sugar in areas of the brain most susceptible to Alzheimer’s.

“If you don’t have as much fuel, you’re not going to be as adept at remembering something or doing something,” Auriel Willette, a scientist in the Department of and Human at Iowa State said. “This is important with Alzheimer’s disease, because over the course of the disease there is a progressive decrease in the amount of blood sugar used in certain brain regions. Those regions end up using less and less.”

“We are terrible at adjusting our behavior based on what might happen in the future,” Willette said. “That’s why people need to know that resistance or related problems with metabolism can have an effect in the here and now on how they think, and it’s important to treat. For Alzheimer’s, it’s not just people with . Even people with mild or moderate resistance who don’t have might have an increased risk for Alzheimer’s disease because they’re showing many of the same sorts of brain and memory relationships.”

The scientists specify that improved and moderate exercise is a crucial prevention at any age. The risk is more immediate in people prone to Alzheimer’s disease. Problems regulating blood sugar may impact at any age.


Auriel A. Willette, Barbara B. Bendlin, Erika J. Starks, Alex C. Birdsill, Sterling C. Johnson, Bradley T. Christian, Ozioma C. Okonkwo, Asenath La Rue, Bruce P. Hermann, Rebecca L. Koscik, Erin M. Jonaitis, Mark A. Sager, Sanjay Asthana. Association of Resistance With Cerebral in Late Middle–Aged Adults at Risk for Alzheimer Disease. JAMA Neurology, 2015; DOI:10.1001/jamaneurol.2015.0613

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