New protein identified to potentially treat diabetes.

sestrine3A newly identified has been linked to proving a new treatment methodology for type 2 diabetes. The Biochemistry and Molecular Biology Department at the IU School of Medicine has published a study examining the impact of sestrin 3 on glucose levels and sensitivity.

Sestrin 3 is a member of a small family of proteins involved in suppressing oxidative stress and regulating normal cellular activity.

Mice models were used to examine the regulatory effects of Sestrin 3 and the animals were fed a diet with 18 percent of its calories from fat or a high-fat diet with 60 percent of calories from fat. The mice without the Sestrin 3 had elevated fasting levels, indicative of impaired sensitivity or poorly regulated glucose .

The mice with Sestrin 3 proteins showed better and glucose tolerance tests were significantly better in the mice with the Sestrin 3 , suggesting that Sestrin 3 plays a critical role in hepatic sensitivity and glucose .

“We wanted to show that Sestrin 3 had critical -specific functions,” Dr. Dong said. “This is a very fascinating . It’s not very big, but it functions in a very dynamic manner controlling glucose production and sensitivity. It is an important regulator for glucose .”


X. Charlie Dong, Ph.D. et al. Sestrin 3 Enhances Hepatic Sensitivity by Direct Activation of the mTORC2-Akt Signaling. Diabetes, November 2014 DOI: 10.2337/db14-0539

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