Researchers from Maynooth University have identified a new protein produced by the human body which may have the potential to impact on obesity related diabetes. Diabetes is a global epidemic and obesity is a key driver of Type 2 Diabetes.
The study directly correlated Pellino3 levels and abdominal fat tissue levels in individuals. Obese individuals had extremely low levels of Pellino3 protein, whereas lean individuals had a high amount. The lower levels of Pellino3 are associated with the production of a critically important pro-inflammatory protein called IL-1 that drives inflammation and ultimately diabetes.
“After nearly three years of research we have identified a new regulatory mechanism for controlling diet-induced diabetes by highlighting a critical role for ‘Pellino3” in regulating inflammation, said Professor Moynagh, the senior study author. “The identification of this new role for Pellino3 is an extremely exciting breakthrough and one that could have important implications for the fight against diseases such as Type 2 Diabetes,” Prof Moynagh said. “My hope is that we can now build on this research and attempt to understand how we may be able to control or manipulate the Pellino3 protein as a method of preventing diabetes disease amongst those at risk.”
Shuo Yang, Bingwei Wang, Fiachra Humphries, Andrew E. Hogan, Donal O’Shea, Paul N. Moynagh. The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance. Immunity, 2014; 41 (6): 973 DOI: 10.1016/j.immuni.2014.11.013