PAT4 protein linked to cancerous tumor growth. Restricting growth impacts on cancer development.

pat4cancerA new study published by has revealed that aggressive cancer manufacture PAT4. PAT4 uses the available cell nutrients from , including healthy tissue.

‘We found that aggressive cancer manufacture more PAT4, which enables them to make better use of available nutrients than the around them – including healthy tissue, said Dr Goberdhan Department of Physiology, Anatomy and Genetics.

The study focused on developing an antibody used to highlight PAT4 in human tissue samples. This was then used to study anonymous tumour samples taken from patients with cancer, a common form of the disease.

Patients who had an increased level of PAT4 in their tumors; did less well than those with lower levels and had a higher relapse rate with increased mortality rate.

‘These findings each other. Not only do higher levels of PAT4 mean a worse outcome, but lowering levels improves the situation. This means that we have identified a mechanism, which cancer prefer to use and which we might be able to as part of a combination treatment,” Dr Goberdhan said.

Source

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in cancer, S-J Fan et al., Oncogene, doi:10.1038/onc.2015.363, published online 5 October 2015

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