Disturbances in the human metabolism have been linked to a variety of diseases. A new study, published in the Journal of Allergy and Clinical Immunology, has revealed that respiratory diseases are initiated and controlled by respiratory diseases.
An imbalance in the human body metabolism can trigger inflammatory processes in the body. These imbalances can be caused by environmental or dietary causes and can trigger an inflammatory immune response.
The study consisted of examining blood samples from newborns and children under one year of age for any possible correlation between metabolites and a corresponding immune reaction. The researchers determined that elevated concentrations of specific sugars, called hexoses, in the blood were correlated with increased concentrations of inflammatory immune parameters.
“Increased concentrations of sugars in the blood therefore do actually lead to the development of an inflammatory immune response, even in newborns. In turn, this is directly correlated with the development of respiratory diseases in early childhood,” said Dr. Gunda Herberth, the lead study author. In-vitro tests carried out by the researchers have confirmed the findings of her epidemiological investigation: In cell cultures, immune cells exposed to hexoses showed elevated concentrations of inflammatory parameters, while those exposed to amino acids inhibited the production of inflammatory components. Dr. Herberth commented: “As certain amino acids can obviously also provide protection from inflammation, we assume that the balance between the metabolites is primarily responsible for the development of inflammatory processes.”
Gunda Herberth, Kirsten Offenberg, Ulrike Rolle-Kampczyk, Mario Bauer, Wolfgang Otto, Stefan Röder, Konrad Grützmann, Ulrich Sack, Jan-Christoph Simon, Michael Borte, Martin von Bergen, Irina Lehmann. Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases. Journal of Allergy and Clinical Immunology, 2015; DOI: 10.1016/j.jaci.2015.01.022