Root of Common Food Allergies Revealed.

 

Research by investigators at Johns Hopkins Children’s Center and the of reveal that a faulty genetic pathway is the leading cause in many including .

The study published in the journal of Science shows that aberrant signaling by a protein called transforming growth factor-beta, or TGF-beta, may be responsible for disrupting the way respond to and environmental allergens, leading to a wide range of allergic disorders.

TGF-beta is well known for its widespread effects in the body, from controlling how cells in a various organs grow and develop to overseeing how they communicate with one another. Mutations in the genes that lead to abnormal TGF-beta signaling are also keys to Marfan and Loeys-Dietz syndromes, marked by blood vessel laxity and dangerous stretching of the aorta, the body’s largest blood vessel.

“We have evidence that the same glitch in TGF-beta that is responsible for some of the seen in Marfan and Loeys-Dietz diseases also lies behind the cascade of events that culminates in the development of conditions like asthma, food allergies and eczema,” says lead investigator Pamela Frischmeyer-Guerrerio, M.D., Ph.D., an at Johns Hopkins Children’s Center.

“Disruption in TGF-beta signaling does not simply nudge to misbehave but appears to singlehandedly unlock the very chain reaction that eventually leads to allergic disease,” says senior investigator Harry “Hal” Dietz, M.D., a cardiologist at Johns Hopkins Children’s Center, professor in the McKusick- Institute of at Hopkins and director of the William S. Smilow Center for Marfan Research.

The present study involved 58 children with LDS, ages 7 to 20, followed at Johns Hopkins. The majority of children had either a history of allergic disease or active allergies, like allergic rhinitis, eczema, food allergies, asthma, and gastrointestinal and esophageal allergic disease. Not surprisingly, these patients also had abnormally high levels of several traditional markers of allergic disease, including IgE — an antibody that drives life-threatening allergic responses — and high numbers of eosinophils, white blood cells involved in allergic reactions.

Because TGF-beta is known to control immune cell maturation, the researchers homed in on a group of cells known as regulatory T cells, which keep tabs on other to ensure that they don’t go into overdrive. LDS patients had unusually high levels of regulatory T cells.  Researchers were suprised when instead of acting in their regular role as inflammation tamers, the regulatory T cells were doing the opposite — secreting allergy-promoting signaling molecules called cytokines. Regulatory T cells obtained from patients with known allergies but without LDS were misbehaving in much the same way, a finding that suggests TGF-beta may induce immune cell malfunction even in the absence of LDS, the researchers say.

To identify precisely how TGF-beta affects immune cell behavior, the researchers next obtained undifferentiated, or naïve, from LDS patients. Immersed in TGF-beta, these “pre-specialized” cells quickly transformed into allergy-promoting known for their ability to recognize and attack pathogens, as well as otherwise innocent substances, like food proteins.

In a final, critical discovery, the researchers found that the of children with LDS had abnormally high levels of a protein called SMAD, a known transmitter of TGF-beta signaling. Yet, LDS patients treated with the blood-pressure medication losartan, known for its ability to tame TGF-beta signaling, had reduced levels of the protein.

Source

P. A. Frischmeyer-Guerrerio, A. L. Guerrerio, G. Oswald, K. Chichester, L. Myers, M. K. Halushka, M. Oliva-Hemker, R. A. Wood, H. C. Dietz. TGF Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease. Science , 2013; 5 (195): 195ra94 DOI: 10.1126/scitranslmed.3006448

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