Selenium found in garlic and broccoli weakens the immune system

broccoligarlicA new study from the has demonstrated that selenium found in garlic and broccoli impacts on by slowing down the immune response. The were published in the Journal of Biological Chemistry and detailed the impact on the immune response.

The immune system normally reacts by removing foreign bodies including cells from the body. Some cells have developed an adaptive mechanism blocking the immune system’s ability to recognize them, allowing to develop unabated. Other cells overexpress immunostimulatory molecules in liquid form. Such over-stimulation has a negative impact on the immune system:

“You can say that the stimulating molecules over-activate the immune system and cause it to collapse, and we are, of course, interested in blocking this mechanism. We have now shown that certain selenium compounds, which are naturally found in, e.g., garlic and broccoli, effectively block the special immunostimulatory molecule that plays a serious role for aggressive cancers such as melanoma, prostate and certain types of ,” said Professor Søren Skov, Department of Veterinary Disease Biology, .

The focus of this study was on the NGK2D ligands, consisting of eight variants. One variant is able to assume liquid form and causes significant serious problems once the is fully developed. The entire bloodstream is, so to speak, infected, and the molecule is therefore used as a marker of serious illness.

“Molecules are found both on the surface of the cells and dissolved in the blood of the affected person. We are now able to show that selenium compounds appear to have a very when it comes to neutralising the special variant of the NGK2D ligand — both in soluble form and when the molecule is placed on the cell surface,” said Professor Søren Skov.

“The overexpression seen in cancers such as melanoma, prostate and certain types of significantly impairs the immune system. If we can find ways to slow down the over-stimulation, we are on the right track. The new results are yet another small step towards better drugs with fewer ,” said Søren Skov.

Source

M. Hagemann-Jensen, F. Uhlenbrock, S. Kehlet, L. Andresen, C. Gabel-Jensen, L. Ellgaard, B. Gammelgaard, S. Skov. The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D. Journal of Biological Chemistry, 2014; 289 (45): 31576 DOI: 10.1074/jbc.M114.591537

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