Taste receptors in gut regulate Diabetes.

tastereceptorimagesResearch from the specifies that receptors in the gut influence Diabetes, identifying taste receptors in other parts of the body than the tongue.

Abnormal control of “” in the human intestine have been described by researchers where taste buds aren’t the only way the body detects .

“When we talk about ‘sweet taste’, most people think of tasting on our tongue, but scientists have discovered that are present in a number of sites in the . We’re now just beginning to understand the importance of the in the human intestine and for sufferers of type 2 diabetes,” Dr Young, the lead says.

Dr. Young contrasted healthy adults with type 2 . He found that the control of in the intestine of the healthy adults enabled their bodies to effectively regulate 30 minutes after exposure to glucose. However, abnormalities in the resulted in more rapid glucose uptake.

“When in the intestine detect glucose, they trigger a response that may regulate the way glucose is absorbed by the intestine. Our studies show that in diabetes patients, the glucose is absorbed more rapidly and in greater quantities than in healthy adults,” Dr Young says.

“This shows that diabetes is not just a disorder of the pancreas and of insulin — the gut plays a bigger role than researchers have previously considered. This is because the body’s own management of glucose uptake may rely on the actions of , and these appear to be abnormally controlled in people with type 2 diabetes.”

“So far, we’ve seen what happens in people 30 minutes after glucose is delivered to the intestine, but we also need to study what happens over the entire period of digestion. There are also questions about whether or not the body responds differently to compared with natural glucose,” he says.

“By gaining a better understanding of how these mechanisms in the gut work, we hope that eventually this will assist to better manage or treat diabetes in the future.”

Source

R. L. Young, B. Chia, N. J. Isaacs, J. Ma, J. Khoo, T. Wu, M. Horowitz, C. K. Rayner. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 2013; DOI: 10.2337/db13-0581

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