Thunder god vine impacts on hepatocellular carcinoma. More potent than current available therapy.

Thunder-God-Vine-3 tumor cancer called Hepatocellular cardinoma is the the second leading globally.

Conventional treatments such as doxorubicin, epirubicin, cisplatin, 5-fluorouracil, etoposide or its combinations have not been effective and the cancer diagnosis has a poor prognosis and life expectancy.

A team of scientists led by the Institute for Basic Science/Seoul National University has examined a library containing hundreds of natural products against a panel of HCC (Hepatocellular ) and discovered that a compound derived from the thunder god vine (Tripterygium wilfordii (Latin) or lei gong teng (Chinese)) was found to be far more potent than current therapies. The thunder god vine has been used as traditional Chinese medicine to treat a range of conditions.

The researchers manufactured a nanogel which increased tumor accumulation and uptake into tumor . The decreasing cell pH efficiently triggered release of the entrapped , reducing the level of two specific proteins called AURKA and CSK2. Increased expression of these proteins and in the correlated with the aggressiveness of cancer. The impact of on protein expression thus significantly lowers the of cancer.


1.Daishun Ling, Hongping Xia, Wooram Park, Michael J. Hackett, Changyeong Song, Kun Na, Kam Man Hui, Taeghwan Hyeon. pH-Sensitive Nanoformulated as a Targeted Therapeutic Strategy for Hepatocellular . ACS Nano, 2014; 8 (8): 8027 DOI: 10.1021/nn502074x

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