Tumeric compound assists brain to repair itself.

tumericResearchers have found that a compound found in tumeric promotes stem and differentiation in the brain, potentially providing a new treatment mechanism for neurological disorders such as Alzheimer’s disease.

The bioactive compound in Turmeric is called aromatic turmerone and previous studies have shown that it blocks the activation of microglial linked to neuro- and activates the brain’s ability to heal itself.

The researchers focused on endogenous neural stem (NSC), found in adult brains. NSC turn into neurons allowing the brain to repair in neurological diseases such as Alzheimer’s.

Rat models were used to test the impact of the compound and it was found that the subventricular zone (SVZ) was wider and the hippocampus expanded in the brains of the rats injected with the compound, compared with those that did not receive the compound. The areas impacted are the two sites in the mammalian brains were the growth of neurons occurs.

To analyze the effect of the compound on regenerative medicine, the researchers cultured and grew rat fetal NSCs in six different concentrations of the compound for 72 hours. It was determined that in certain concentrations the compound increased NSC proliferation by up to 80% without impacting whatsoever. In addition, the cell differentiation process sped up in the treated with the compound, compared with the untreated control .

“While several substances have been described to promote stem in the brain, fewer drugs additionally promote the differentiation of stem into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal,” said lead Adele Rueger.


Aromatic-turmerone induces neural stem in and in vivo, Maria Adele Rueger, et al., Stem Cell & Therapy, doi:10.1186/scrt500, published 26 September 2014, abstract.

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