Vitamin deficiency linked to Multiple Sclerosis through genetic analysis

ms 2Prior studies have determined a link between and metabolic sclerosis. A new study from McGill University in Canada has determined that caused by genetic expression is linked to increasing the risk of MS by 50%.

The study examined 14,498 people with multiple sclerosis and 24,091 healthy controls and used a Mendelian technique to analyze the association between genetically reduced levels, (measured by an existing levels of 25-hydroxyvitamin D, the clinical determinant of status). The scientists determined that a genetic decrease in the level by one standard deviation was associated with a 2-fold increased risk of multiple sclerosis and recommend- further clinical trials.

Previous studies have confirmed the link between the onset of multiple sclerosis (MS) and low levels of . The estimates that 2.5 million people are affected by multiple sclerosis. MS is a central nervous system disease characterised by problems with muscle control and strength, vision, balance, feeling, and thinking. The new study is one of the first to examine levels from the onset of symptoms of their disease.

“Because low levels are common and can be easily and safely increased by oral supplementation, these findings may contribute to better outcomes for many MS patients,” said lead author Alberto Ascherio, professor of epidemiology and at (HSPH).

“The benefits of appeared to be additive to those of interferon beta-1b, a drug that is very effective in reducing MS activity. The findings of our study indicate that identifying and correcting insufficiency should become part of the standard of care for newly diagnosed MS patients,” said Ascherio.

The study consisted of analyzing data obtained from 465 MS patients from 18 European countries, Israel, and Canada who enrolled in 2002 and 2003 in the BENEFIT (Betaseron in Newly Emerging Multiple Sclerosis for Initial Treatment) trial, which was aimed at comparing the effectiveness of early versus late interferon beta-1b in treating the disease. The researchers examined levels of correlated with disease symptoms and progression over a period of five years.

It was found that early stage MS patients with adequate levels of had a 57% lower rate of new brain lesions, a 57% lower relapse rate, and a 25% lower yearly increase in lesion volume than those with lower levels of . The study also confirmed that loss in brain volume, was lower among patients with adequate levels.


Alberto Ascherio, Kassandra L. Munger, Rick White, Karl Köchert, Kelly Claire Simon, Chris H. Polman, Mark S. Freedman, Hans-Peter Hartung, David H. Miller, Xavier Montalbán, Gilles Edan, Frederik Barkhof, Dirk Pleimes, Ernst-Wilhelm Radü, Rupert Sandbrink, Ludwig Kappos, Christoph Pohl. as an Early Predictor of Multiple Sclerosis Activity and Progression. JAMA Neurology, 2014; DOI: 10.1001/jamaneurol.2013.5993

Mokry LE, Ross S, Ahmad OS, Forgetta V, Smith GD, Leong A, et al. and Risk of Multiple Sclerosis: A Mendelian Study. PLoS Med, 2015 DOI: 10.1371/journal.pmed.1001866

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