Effect of poor eating habits changes gene expression.

dietA new study has determined that the effects of poor eating habits carries on long after people have changed to a healthy lifestyle. In a new study published in the Journal of Leukocyte Biology, scientists used mice to reveal that even after a complete life style change the effects of an unhealthy life style still impacted on the way the immune system functions.

This change in function is attributed to as there are poor eating habits that alter the way genes express themselves, including genes related to immunity. This change in expression () ultimately keeps the risk of cardiovascular disorders higher than it would be had there been no exposure to unhealthy foods in the first place.

For this study scientists used two groups of mice who contained an altered making them more susceptible to developing high blood cholesterol and atherosclerosis. These mice were either fed a high-fat, high-cholesterol diet (Western-type diet, WTD) or a normal diet (chow). It was determined that DNA methylation, an epigenetic signature, in the bone marrow was different in mice that received bone marrow from the WTD-fed donors compared to the mice receiving bone marrow from chow-fed donors. Furthermore, these mice had large differences in their immune system and increased atherosclerosis.

“We’ve long known that lifestyle and nutrition could affect immune system function,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “The ability of nutritional history to have durable affects on immune demonstrated in this new report could have profound implications for treatment of diseases with immune underpinnings. The length of such effects will be critical to determine and it will be interesting to examine the effects of drugs that can modify .”


E. van Kampen, A. Jaminon, T. J. C. van Berkel, M. Van Eck. Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis. Journal of Leukocyte Biology, 2014; 96 (5): 833 DOI: 10.1189/jlb.1A0114-017R

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