The United States Department of Health and Human Services released a summary of adverse reactions in response to 7259 adverse reactions reported by the public.
Scientific studies confirm the adverse reactions and more recent studies point to a more significant health risk than the general public might be aware of.
The Departments of Toxicology and Narcotics, and Medical Biochemistry, National Research Centre in Egypt released their dose dependent aspartame research in December of 2012. The study suggests that repeated aspartme administration resulted in impaired memory performance and increased brain oxidative stress.
For the average consumer this means that daily consumption of aspartame based sweeteners in sodas or as an overall sugar replacement could have a significant health impact.
Abdel-Salam OM, Salem NA, El-Shamarka ME, Hussein JS, Ahmed NA, El-Nagar ME. Eur Rev Med Pharmacol Sci. 2012 Dec;16(15):2092-101. Studies on the effects of aspartame on memory and oxidative stress in brain of mice.