Gut bacteria contributes to development of diabetes

diabA study presented by the University of Illinois at the ENDO 2015 meeting in San Diego has pointed to the fact that lack of beneficial gut bacteria contributes to an elevated for developing type 2 diabetes. The findings examined the impact on African Americans who are considered to be high for the disease. More and more studies are focusing on the impact of gut bacteria, its ability to fight infections, and how it plays an important role in keeping the immune system healthy.

The participants consisted of 116 African-American male veterans, aged 45 to 75, who participated in the D Vitamin Intervention in VA, or DIVA study. The DIVA study was initiated to determine if vitamin D supplementation can prevent diabetes in men with factors for developing the disease. The were divided into four groups based on changes in their blood sugar levels as determined at the start and end of the one-year study. The groups included men whose glucose levels remained normal (non-pre-diabetic); those with stable levels indicative of pre-diabetes; those whose levels indicated a worsening of glucose control; and those whose levels improved. All the men provided stool samples for analysis of their gut microbiota.

The findings revealed that men whose blood sugar levels stayed normal over the year had more gut bacteria that are considered beneficial for metabolic , whereas those who stayed pre-diabetic had fewer beneficial bacteria and more harmful bacteria. In addition, the group whose levels improved had more abundant Akkermansia—healthy bacteria—than the group that maintained normal blood sugar control throughout the year.

“The study provides additional reasons for physicians to recommend foods, such as prebiotics, which improve the growth and activity of helpful gut bacteria,” said principal investigator Dr. Elena Barengolts.


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