Healthy heart lowers risk of Alzheimer’s Disease and Dementia

heart A new research study has linked having a healthy heart to a much lower risk of Alzheimer’s disease and dementia. The research findings published by the Medical Center, in the journal Circulation, revealed that research participants with decreased heart function, measured by cardiac index, were two to three times more likely to develop significant memory loss over the follow-up period. The study also highlights the benefits of a healthy life style.

The data used for this study was based on the Framingham Heart Study, which began in 1948 to identify for heart disease. 1,039 participants from Framingham’s Cohort were followed for up to 11 years to compare cardiac index to the development of dementia.

“Heart function could prove to be a major risk factor for dementia and Alzheimer’s disease,” said Angela Jefferson, Ph.D., director of the Vanderbilt Memory & Alzheimer’s Center, and principal investigator of the study. “A very encouraging aspect of our findings is that heart health is a modifiable risk. You may not be able to change your genetics or family history, but you can engage in a heart healthy lifestyle through diet and exercise at any point in your lifetime.”

During the study 32 participants developed dementia, including 26 cases of Alzheimer’s disease. Compared to normal cardiac index, individuals with clinically low cardiac index had a higher relative risk of dementia.

“Cardiac index is a measure of heart health. It reflects cardiac output or the amount of blood that leaves the heart and is pumped through the body taking into consideration a person’s body size. A low cardiac index value means there is less blood leaving the heart,” Jefferson said.

“We thought heart disease might be driving the increased risk of dementia and Alzheimer’s disease. When we excluded participants with heart disease and other heart conditions, we were surprised that the risk of dementia and Alzheimer’s disease got even worse,” Jefferson said.

“For the average adult, the brain accounts for 2 percent of overall body weight but receives as much as 15 percent of blood leaving the heart. If there are changes in the heart’s ability to pump blood, the brain is resilient and does a great job at regulating blood flow to maintain a consistent level to support brain tissue and activity. But as we age, our vessels tend to be less healthy. They become less adaptable to blood flow changes, and those changes may affect brain health and function,” she said.

“The risk we found between lower cardiac index and the development of dementia may reflect a subtle but protracted process that occurs over decades –essentially a lifetime burden of subtle reductions in oxygen and nutrient delivery to the brain. That possibility is concerning given the observation that one in three participants in our study met the medical definition for low cardiac index.”


Low cardiac index is associated with incident dementia and Alzheimer’s disease: the Framingham Heart Study, Angela L. Jefferson, et al., Circulation, doi:10.1161/CIRCULATIONAHA.114.012438, published online 19 February 2015, abstract.

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