Insulin resistance linked to Gene

geneA new study has determined that a variant is responsible for insulin resistance, highlighting how little researchers actually know about the disease. Diabetes has become a burden and approximately one third of the U.S. population has insulin resistance.

Insulin resistance occurs in the vast majority of patients who eventually develop type 2 diabetes and seems to be a necessary, but not sufficient, abnormality leading to hyperglycemia in these individuals. Insulin-resistant persons who continue to secrete insulin are still at increased risk to develop . It is estimated that 25% to 33% of the US population is sufficiently insulin resistant to be at risk for adverse clinical consequences.

The research analysis by Stanford University examined the in over 5,000 individuals and found that the presence of one specific variant, called -acetyltransferase 2 (NAT2) is associated with for diabetes and heart disease.

Using a mouse model the researchers found that inhibiting the NAT2 homolog decreased insulin sensitivity. A homolog is defined as a member of a chromosome pair. The NAT@ has not been previously associated with insulin resistance.

Source

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity J Clin Invest. 2015;125(4):1739–1751. doi:10.1172/JCI74692.

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