Music regulates genes

musicA previous study has explored the positive impact of music, art and nature on the immune system. Now a new research study has explained that the connection is deeper than previously thought and has the ability to affect gene expression, specifically those involved with the brain.

The consisted of people who were familiar with classical music and those who were not. All were exposed to W.A. Mozart’s violin concert Nr 3, G-major, K.216 for 20 minutes. Listening to music enhanced the activity of involved in dopamine secretion and transport, synaptic function, . One of the most up-regulated , synuclein-alpha (SNCA) is a known gene for Parkinson’s disease and is located in the area associated with musical aptitude. In contrast, listening to music down-regulated that are associated with neurodegeneration, suggesting that music neurons have a neuroprotective impact.

The neuroprotective impact was only observed in participants who were exposed to previous music suggesting that music therapy may have a preventative impact.

“The up-regulation of several that are known to be responsible for song learning and singing in songbirds suggest a shared evolutionary background of sound perception between vocalizing birds and humans,” said Dr. Irma Järvelä, the leader of the study.


Chakravarthi Kanduri, Pirre Raijas, Minna Ahvenainen, Anju K. Philips, Liisa Ukkola-Vuoti, Harri Lähdesmäki, Irma Järvelä. The effect of listening to music on human transcriptome. PeerJ, 2015; 3: e830 DOI: 10.7717/peerj.830

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