New study revealed that tamoxifen combined with caffeine halves the risk of recurrence of breast cancer

coffee2A new study released by Lund University in Sweden has revealed that women with who were placed on a regiment of tamoxifen could halve the risk of recurrence by consuming . is the most common cause of cancer. with at least one in eight women affected. At least 2 cups of a day halved the risk of recurrence in tamoxifen treated women. The study is the first to examine the detailed metabolic connection in contrast to the previous study which only examined the indirect causation.

“Now, unlike in the previous study, we have combined information about the patients’ lifestyle and clinical data from 1,090 patients with studies on ,” say researchers Ann Rosendahl and Helena Jernström, both of Lund University and Skåne University Hospital, also in Sweden.

Tamoxifen is the most common treatment for patients with estrogen receptor positive (ER) . The consisted of 1,090 women and 500 women were treated with tamoxifen. The women’s consumption was assessed and allocated to one of three categories: low consumption (less than one cup a day), moderate consumption (two to four cups and day) and high consumption (five or more cups a day).

The research findings specifically revealed that tamoxifen-treated women who consumed at least two cups of a day had smaller tumors and a lower proportion of hormone-dependent tumors than women who consumed less . The team found that both of these compounds – particularly – reduced cell division and increased cell death among both ER+ and estrogen receptor-negative (ER-) . When tamoxifen was applied, the effect was even stronger.

“This shows that these substances have an effect on the and turn off signaling pathways that the cancer require to grow,” said Rosendahl and Jernström. The researchers attribute the anticancer impact of to the anti-oxidant properties of . “The clinical and experimental findings demonstrate various anticancer properties of and caffeic acid against both ER+ and ER- that may sensitize tumor to tamoxifen and reduce growth.”


and caffeic acid inhibit growth and modify estrogen receptor and insulin-like growth factor I receptor levels in human , Ann Rosendahl, Helena Jernström, et al., Clinical , doi: 10.1158/1078-0432.CCR-14-1748, published online 15 April 2015.

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