Turmeric effective therapeutic agent. Bioactive compound increased with hydrophilic carrier.

tumericA new study, published in the Journal of the American College of Nutrition, has showcased a new hydrophilic carrier which maximizes the ability of curcumin, desmethoxycurcumin and bisdemethoxycurcumin to be absorbed by the human .

Curcumin has many biological positive effects including anti-inflammatory, antioxidant, antitumor, antibacterial and antiviral activities and has been used to treat many diseases and metabolic conditions. Turmeric is traditionally consumed in a fat based sauce such as in fat rich yellow curry, milk, ghee, or coconut milk, as bioactive compounds have been impacted by poor intestinal absorption, rapid metabolism and limited systemic bioavailability. In other words, the bioactive compounds are not absorbed unless they are available in a fat based solution.

A new hydrophilic carrier demonstrated that a curminoid metabolite formula was dispered with 49.5 times the effectiveness of previous standard purified curminoid solutions.

Tumeric improves the of people who are in the early stages of diabetes and risk cognitive impairment. A study conducted in Taiwan has confirmed the positive health benefits of Tumeric with just one gram a day acting as an early intervention method.

The research participants consisted of a working of men and women aged 60 or older who had been diagnosed with untreated pre-diabetes. Subjects were provided with one gram of tumeric in conjunction with a bland breakfast.Their working was tested before and after the meal.

“Working is widely thought to be one of the most important mental faculties, critical for cognitive abilities such as planning, problem solving and reasoning,” Professor Wahlqvist one of the lead study authors said.

“We found that this modest addition to breakfast improved working over six hours in older people with pre-diabetes,” Professor Wahlqvist said.

The research findings confirms existing research which reduces the risk of dementia. “Our findings with turmeric are consistent with these observations, insofar as they appear to influence cognitive function where there is disordered and insulin resistance,” said Professor Wahlqvist.

Researchers have found that a compound found in tumeric promotes stem and differentiation in the brain, potentially providing a new treatment mechanism for neurological disorders such as Alzheimer’s disease.

The bioactive compound in Turmeric is called aromatic turmerone and previous studies have shown that it blocks the activation of microglial linked to neuro-inflammation and activates the brain’s ability to heal itself.

The researchers focused on endogenous neural stem (NSC), found in adult brains. NSC turn into neurons allowing the brain to repair brain functions in neurological diseases such as Alzheimer’s.

Rat models were used to test the impact of the compound and it was found that the subventricular zone (SVZ) was wider and the hippocampus expanded in the brains of the rats injected with the compound, compared with those that did not receive the compound. The areas impacted are the two sites in the mammalian brains were the growth of neurons occurs.

To analyze the effect of the compound on regenerative medicine, the researchers cultured and grew rat fetal NSCs in six different concentrations of the compound for 72 hours. It was determined that in certain concentrations the compound increased NSC proliferation by up to 80% without impacting whatsoever. In addition, the cell differentiation process sped up in the treated with the compound, compared with the untreated control .

“While several substances have been described to promote stem in the brain, fewer drugs additionally promote the differentiation of stem into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal,” said lead researcher Adele Rueger.

A study by Ohio State university, published in PLOS ONE journal, has demonstrated the impact of curcumin’s biological effects on the entire body.

“There’s a reason why this compound has been used for hundreds of years in Eastern medicine. And this study suggests that we have identified a better and more effective way to deliver curcumin and know what diseases to use it for so that we can take advantage of its anti-inflammatory power,” said Nicholas Young, a postdoctoral researcher in rheumatology and immunology at Ohio State and lead author of the study.

The study consisted of feeding mice models with a curcumin based nutritional substance. The research findings revealed that curcumin acts by blocking activation of a key that triggers the immune response. The researchers were also the first to show that curcumin stops recruitment of specific immune that, when overactive, are linked to such problems as heart disease and obesity.In a specialized imaging machine, mice receiving plain curcumin lit up with bioluminescent signals indicating that NF-kB was actively triggering an immune response, while mice receiving nano-emulsified curcumin showed minimal signs — a 22-fold reduction — that the had been activated at all.

“We envision that this nutraceutical could be used one day both as a daily supplement to help prevent certain diseases and as a therapeutic drug to help combat the bad inflammation observed in many diseases,” Young said. “The distinction will then be in the amount given — perhaps a low dose for daily prevention and higher doses for disease suppression.”

Source

Nicholas A. Young, Michael S. Bruss, Mark Gardner, William L. Willis, Xiaokui Mo, Giancarlo R. Valiente, Yu Cao, Zhongfa Liu, Wael N. Jarjour, Lai-Chu Wu. Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration. PLoS ONE, 2014; 9 (11): e111559 DOI: 10.1371/journal.pone.0111559

Aromatic-turmerone induces neural stem in vitro and in vivo, Maria Adele Rueger, et al., Stem Cell Research &; Therapy, doi:10.1186/scrt500, published 26 September 2014, abstract.

Meei-Shyuan Lee, Mark L Wahlqvist, Yu-Ching Chou, Wen-Hui Fang, Jiunn-Tay Lee, Jen-Chun Kuan, Hsiao-Yu Liu, Ting-Mei Lu, Lili Xiu, Chih-Cheng Hsu, Zane B Andrews, Wen-Harn Pan. Turmeric improves post-prandial working in pre-diabetes independent of insulin. Asia Pac J Clin Nutr., 2014;23 DOI: 10.6133/apjcn.2014.23.4.24

Brad J. Douglass, Dallas L. Clouatre. Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies. Journal of the American College of Nutrition, 2015; 34 (4): 347 DOI: 10.1080/07315724.2014.950392

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